個人簡介

李永欣，男，理學博士，碩士生導師。近年來主要關注于醫學影像技術在神經系統疾病的應用研究，從臨床的實際問題出發，通過多模态核磁共振成像方法對抑郁症、腦卒中和兒童癫痫等常見神經疾病的影像學表現以及治療前後的影像學變化進行研究，以期加深對相關疾病的内在神經機制的理解，為臨床活動提供影像學方面的指導，服務于臨床診療工作。整體研究工作偏重于基礎研究，在此基礎上尋找臨床應用轉換的潛在價值。

教學/科研成果

①課題：

1. 廣東省醫學科研基金項目，基于靜息态功能磁共振成像動态腦網絡技術對兒童特發性全身性癫痫發病機制的研究，202011249354630, 2021.07.01-2023.06.30，1萬元，主持

2. 國家自然科學基金青年科學基金項目，81601483，基于多模态神經影像學的特發性全身性兒童癫痫腦網絡的研究，2017/01-2019/12，17萬，主持

3. 中國博士後科學基金面上項目，2017M610538, 多模态磁共振成像對兒童特發全身性癫痫腦網絡的研究, 2016/03-2018/12, 8萬，主持

4. 中國博士後科學基金面上項目，2015M572337，多參數時空動态成像系統對活體肺癌組織代謝機制的研究，2015/01-2016/12，5萬，主持

5. 國家自然科學基金重大儀器專項基金項目，61427807，活體腫瘤組織代謝信号多參數時空動态成像系統研究，2015/01-2019/12，510萬，參與

6. 廣東省自然科學基金，2016A030310402，基于多模态神經影像學的特發性全身性兒童癫痫腦網絡的研究，2016/06-2019/6，10萬，主持

②論文：

1. Li, Yongxin, Yu, Zeyun, Wu, Ping, Chen, Jiaxu. (2021). The disrupted topological properties of structural networks showed recovery in ischemic stroke patients: a longitudinal design study. BMC Neuroscience. 2021, 22: 47.

2. Yongxin Li*, Qian Chen, Wenhua Huang, Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures. Brain and Behavior, 2020: e01890.

3. Huang Jiabin#, Li Yongxin#*, Xie Huijun, Yang Shaomin, Jiang Changyu, Sun Wuping, Li Disen, Liao Yuliang, Ba Xiyuan, Xiao Lizu*, Abnormal Intrinsic Brain Activity and Neuroimaging-Based fMRI Classification in Patients With Herpes Zoster and Postherpetic Neuralgia, Frontiers in Neurology, 2020, 11(1181): 532110

4. Yongxin Li*, Ya Wang, Yanfang Wang, Huirong Wang, Ding Li, Qian Chen, Wenhua Huang*, Impaired topological properties of gray matter structural covariance network in epilepsy children with generalized tonic-clonic seizures: A graph theoretical analysis, Frontiers in neurology, 2020, 11: 253.

5.Yongxin Li*, Zhen Tan, Z, Ya Wang, Yanfang Wang, Ding Li, Qian Chen, Wenhua Huang. Detection of differentiated changes in gray matter in children with progressive hydrocephalus and chronic compensated hydrocephalus using voxel-based morphometry and machine learning.  Anatomical Record. 2020; 303: 2235– 2247.

6.Jianping Wang, Yongxin Li*, Ya Wang, Wenhua Huang, Multimodal data and machine learning for detecting specific biomarkers in pediatric epilepsy patients with generalized tonic-clonic seizures, Frontiers in neurology, 2018, 9: 1038.

7. Yongxin Li, Ya Wang, Zhen Tan, Ding Li, Qian Chen*, Wenhua Huang*, Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with drug-resistant epilepsy, Epilepsy & Behavior Case Reports, 2019, 11: 58-66. 

8.  Yongxin Li#, Zhen Tan#, Jianping Wang, Ya Wang, Yungen Gan,  Feiqiu Wen,  Qian Chen*, Derek Abbott, Kelvin K. L. Wong,Wenhua Huang*, Alterations in Spontaneous Brain Activity and Functional Network Reorganization following Surgery in Children with Medically Refractory Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study, Frontiers in neurology, 2017, 8: 374.

9. Ya Wang, Yongxin Li*, Huirong Wang, Yanjun Chen, Wenhua Huang*, Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms, Frontiers in Neurology, 2017, 8: 209.

10.Yongxin Li, Ya Wang, Chenxi Liao, Wenhua Huang*, Ping Wu*, Longitudinal brain functional connectivity changes of the cortical motor-related network in subcortical stroke patients with acupuncture treatment,Neural Plasticity, 2017, 2017: 5816263.

11.Yongxin Li#, Defeng Wang#, Heye Zhang, Ya Wang, Ping Wu, Hongwu Zhang, Yang Yang, Wenhua Huang*. Changes of Brain Connectivity in the Primary Motor Cortex after Subcortical Stroke: A Multimodal MRI Study. Medicine, 2016，95(6):e2579

12.Yongxin Li, Feiyan Chen, Wenhua Huang*, Neural plasticity following abacus training in humans: a review and future directions, Neural Plasticity, 2016, 2016: 1213723

13.Yongxin Li, Cailei Zhao, Zhen Tan, Ya Wang, Heye Zhang, Jinyang Wang, Honghua Guo, Baozhen Zeng, Wenhua Huang*. Longitudinal changes in the brain following third ventriculostomy in a child with hydrocephalus: case report, Medicine, 2015, 94(47): e2095.

14.Yongxin Li#, Ya Wang#, Heye Zhang, Ping Wu*, Wenhua Huang*.The effect of acupuncture on the motor function and white-matter microstructure in ischemic stroke patients, Evidence-Based Complementary and Alternative Medicine, 2015, 2015:164792.

15.李永欣,劉哲星，黃文華等. 擴散張量成像數據分析方法概述. 中國醫學影像技術2015, 31(6): 134-137.

16.Zhen Tan#, Yongxin Li#, Fengjun Zhu, Dongdong Zang, Cailei Zhao, Cong Li, Dan Tong, Heye Zhang*, Qian Chen*，Children with Intracranial Arachnoid Cysts: Classification and Treatment， Medicine， 2015, 94(44): e1749

17.Yongxin Li #, Ping Wu#, Fanrong Liang*, Wenhua Huang*, The microstructural status of the corpus callosum is associated with the degree of motor function and neurological deficit in stroke patients, Plos one, 2015, 10(4): e0122615.

18.Yongxin Li, Yuzheng Hu, Ming Zhao, Yunqi Wang, Jian Huang, Feiyan Chen*, The neural pathway underlying a match-to-sample task in abacus-trained children and associated functional connectivity in the resting brain, Brain Research, 2013, 1539: 24-33.

19.Yongxin Li, Yunqi Wang, Yuzheng Hu, Feiyan Chen*, Structural changes in left fusiform areas and associated fiber connections in children receiving abacus training: Evidence from morphometry and tractography, Frontiers in Human Neuroscience, 2013, 7: 00335.

20.Yongxin Li, Yuzheng Hu, Jian Weng, Wangyun Qi, Feiyan Chen*, Individual structural differences in left inferior parietal area are associated with schoolchildrens’ arithmetic scores; Frontiers in Human Neuroscience, 2013, 7: 00844.

專著：

系統解剖學,北京：科學出版社 2018.05, 編者

學術兼職

自2018年6月聘任為廣東省生物醫學工程學會生物力學分委會委員。